Cine tracer alternative
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All LVEF, ESV and EDV values were compared to the reference values assessed by weighing. LVEF was also calculated for planar ERNA images. LVEF was also measured from PET images converted to 2D “pseudo-planar” images along the short axis and horizontal long axis.
Cine tracer alternative manual#
EDV, ESV, and/or LVEF were measured by manual and automated cardiac cavity delineation, using clinical segmentation softwares. PET/CT (3-s acquisitions), MRI, and planar and SPECT ERNA were performed. Reference left ventricle end-diastole volume (EDV), end-systole volume (ESV), and LVEF were determined by phantom weights before/after water filling. Heart phantoms in end-diastole and end-systole were 3D-printed from a patient’s MRI dataset. This study determined whether digital PET/CT accurately measured LVEF in an anthropomorphic heart phantom under conditions mimicking radiotracer first-pass into the cardiac cavities. Ultra-sensitive digital PET systems can produce high-quality images within 3-s acquisition times. It would be clinically useful to measure LVEF from first-pass positron-emission tomography/computed tomography (PET/CT) radionuclide angiography, but this approach has been limited by fast radiotracer diffusion. Left ventricular ejection fraction (LVEF) is usually measured by cine-cardiac magnetic resonance imaging (MRI), planar and single-photon emission-computerized tomography (SPECT) equilibrium radionuclide angiocardiography (ERNA), and echocardiography.